Metalloenzymes for Methane Activation

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Seattle, Washington
Project Term:
01/01/2014 - 09/30/2015

Technology Description:

The team from Arzeda will use computational enzyme design tools and their knowledge of biological engineering and chemistry to create new synthetic enzymes to activate methane. Organisms that are capable of using methane as an energy and carbon source are typically difficult to engineer. To address this challenge, Arzeda will develop technologies essential to creating modular enzymes that can be used in other organisms. The team will combine computation enzyme design with experimental methods to improve enzyme activity and help direct methane more effectively into metabolism for fuel production. Arzeda’s new enzymes could transform the way methane is activated, and would be more efficient than current chemical and biological approaches.

Potential Impact:

If successful, Arzeda’s enzymes will efficiently activate methane for cost-effective fuel production, and could also be applied to a variety of other synthesis processes for fuels and chemicals.


An improved bioconversion process could create cost-competitive liquid fuels significantly reducing demand for foreign oil.


This technology would allow for utilization of small-scale remote natural gas resources or methane and carbon rich gas residues for fuel production reducing harmful emissions associated with conventional fuel technologies.


Expanding U.S. natural gas resources via bioconversion to liquid fuels could contribute tens of billions of dollars to the nation's economy while reducing or stabilizing transport fuel prices.


ARPA-E Program Director:
Dr. Marc von Keitz
Project Contact:
Dr. Daniela Grabs
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Project Contact Email:

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